Laboratory for Evolutionary Cell Biology of the Skin
School of Bioscience and Biotechnology
Tokyo University of Technology
Skin epidermis is the outer most barrier of our body. The skin surface is composed of dead stratum corneum which serves as air-liquid interface barrier. To understand the formation of this functional barrier, we focus to the final living layer, stratum granulosum cells (SG1). In combination with light and electron microscopic techniques, we are dissecting how the SG1 cells die termed ‘corneoptosis’ and form SC during cornification process. Particularly, we will study comparative evolutionary cell biology of SG1 cells in various terrestrial vertebrates (amphibians, reptiles, aves and mammals) to understand the adaptive evolution of epithelial cells.