{"id":9,"date":"2019-03-19T18:46:16","date_gmt":"2019-03-19T09:46:16","guid":{"rendered":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/?page_id=9"},"modified":"2023-05-22T10:52:48","modified_gmt":"2023-05-22T01:52:48","slug":"%e7%a0%94%e7%a9%b6%e5%86%85%e5%ae%b9","status":"publish","type":"page","link":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/?page_id=9","title":{"rendered":"\u7814\u7a76\u5185\u5bb9 (Japanese)"},"content":{"rendered":"\n<p>Research in Japanese<\/p>\n\n\n\n<p><strong>\u3010\u7f8e\u3057\u3044\u808c\u306f\u3069\u306e\u3088\u3046\u306b\u3067\u304d\u308b\u306e\u304b\uff1f\u76ae\u819a\u306e\u9069\u5fdc\u9032\u5316\u304b\u3089\u8003\u3048\u308b\u89d2\u5c64\u30d0\u30ea\u30a2\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u3011<\/strong><\/p>\n\n\n\n<p>\u3000\u79c1\u9054\u306e\u7f8e\u3057\u3044\u808c\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u4f5c\u3089\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n<p>\u76ae\u819a\u306f\u4eba\u4f53\u306e\u4e2d\u3067\u306e\u6700\u5927\u306e\u81d3\u5668\u3067\u3059\u3002\u76ae\u819a\u306f\u5916\u5074\u304b\u3089\u8868\u76ae\u30fb\u771f\u76ae\u30fb\u76ae\u4e0b\u7d44\u7e54\u304b\u3089\u306a\u308a\u3001\u8868\u76ae\u306f\u300c\u91cd\u5c64\u6241\u5e73\u4e0a\u76ae\u7d44\u7e54\u300d\u3068\u547c\u3070\u308c\u308b\u591a\u5c64\u69cb\u9020\u3092\u6301\u3063\u305f\u4e0a\u76ae\u7d44\u7e54\u3067\u3059\u3002\u8868\u76ae\u306f\u3001\u4e3b\u306b\u57fa\u5e95\u5c64\u3001\u6709\u68d8\u5c64\u3001\u9846\u7c92\u5c64\u3001\u89d2\u5c64\uff08\u89d2\u8cea\u5c64\uff09\u304b\u3089\u3067\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/wp-content\/uploads\/2021\/05\/image-2.png\" alt=\"\" class=\"wp-image-385\"\/><\/figure>\n\n\n\n<p>\u808c\u306e\u8868\u9762\u306b\u3042\u308b\u76ae\u819a\u8868\u76ae\u306e\u6700\u3082\u5916\u5074\u306b\u3042\u308b\u89d2\u5c64\u306f\u6b7b\u3093\u3060\u7d30\u80de\u5c64\uff08\u7d04\u6570\u5c64\u301c\u6570\u5341\u5c64\uff09\u304b\u3089\u306a\u308a\u307e\u3059\u3002\u89d2\u5c64\u306f\u3001\u4e21\u751f\u985e(\u6210\u4f53)\u30fb\u722c\u866b\u985e\u30fb\u9ce5\u985e\u30fb\u54fa\u4e73\u985e\u306e\u3088\u3046\u306a\u9678\u4e0a\u810a\u690e\u52d5\u7269\u306e\u307f\u304c\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u89d2\u5c64\u304c\u30d0\u30ea\u30a2\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u306b\u3088\u308a\u3001\u9678\u4e0a\u751f\u6d3b\u3092\u55b6\u3080\u3053\u3068\u304c\u3067\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>&nbsp;\u3000\u5730\u7403\u3068\u9032\u5316\u306e\u6b74\u53f2\u3092\u9061\u308b\u3068\u3001\u30c7\u30dc\u30f3\u7d00\u5f8c\u671f\uff08\u7d043\u51046\u5343\u4e07\u5e74\u524d\uff09\u306b\u4e21\u751f\u985e\u304c\u3001 \u80ba\u3084\u56db\u80a2\u306e\u9032\u5316\u3068\u5171\u306b\u3001\u76ae\u819a\u8868\u306b\u89d2\u5c64\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u3067\u3001\u9678\u4e0a\u9032\u51fa\u304c\u6210\u3057\u9042\u3052\u3089\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u306b\u51fa\u73fe\u3057\u305f\u722c\u866b\u985e\u306b\u306f\u3001\u3088\u308a\u9678\u4e0a\u3067\u306e\u751f\u80b2\u306b\u9069\u3057\u305f\u5f37\u56fa\u3067\u30d0\u30ea\u30a2\u80fd\u304c\u767a\u9054\u3057\u305f\u89d2\u5c64\u304c\u7372\u5f97\u3055\u308c\u3001\u9ce5\u985e\u3067\u306f\u7fbd\u3092\u7372\u5f97\u3057\u3064\u3064\u67d4\u3089\u304b\u304f\u4fdd\u6e7f\u80fd\u304c\u306a\u3044\u89d2\u5c64\u3078\u3068\u5909\u5316\u3057\u307e\u3057\u305f\u30022\u51043\u5343\u4e07\u5e74\u524d\u306b\u306f\u3001\u722c\u866b\u985e\u578b\u54fa\u4e73\u985e\u304b\u3089\u79c1\u305f\u3061\u306e\u7956\u5148\u3067\u3042\u308b\u54fa\u4e73\u985e\u304c\u51fa\u73fe\u3057\u307e\u3057\u305f\u304c\u3001\u6bdb\u3084\u4e73\u817a\u306e\u7372\u5f97\u3068\u5171\u306b\u3001\u67d4\u3089\u304b\u304f\u4fdd\u6e7f\u3055\u308c\u305f\u89d2\u5c64\u304c\u7372\u5f97\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306b\u3001\u751f\u80b2\u74b0\u5883\u5909\u5316\u3068\u5171\u306b\u51fa\u73fe\u3057\u305f\u69d8\u3005\u306a\u9678\u4e0a\u810a\u690e\u52d5\u7269\u306f\u3001\u4f53\u8868\u9762\u306e\u89d2\u5c64\u3092\u9032\u5316\u3055\u305b\u3001\u65b0\u3057\u3044\u74b0\u5883\u306b\u9069\u5fdc\u3057\u3066\u304d\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u69d8\u3005\u306a\u9678\u4e0a\u810a\u690e\u52d5\u7269\u306e\u89d2\u5c64\u306e\u5f62\u6210\u904e\u7a0b\u306e\u4e2d\u306b\u3001\u7d30\u80de\u306e\u9069\u5fdc\u9032\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u304f\u9375\u304c\u96a0\u3055\u308c\u3066\u304a\u308a\u3001\u79c1\u9054\u54fa\u4e73\u985e\u306e\u7f8e\u3057\u3044\u808c\u304c\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u3066\u304d\u305f\u306e\u304b\u3001\u3055\u308c\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/wp-content\/uploads\/2021\/05\/image-3.png\" alt=\"\" class=\"wp-image-388\"\/><\/figure>\n\n\n\n<p>\u3000\u89d2\u5c64\u306f\u3001\u9846\u7c92\u5c64\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u751f\u304d\u305f\u7d30\u80de\u304c\u3001\u7279\u6b8a\u306a\u7d30\u80de\u6b7b\u3092\u884c\u3044\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u9032\u5316\u306e\u904e\u7a0b\u3067\u3001\u9846\u7c92\u5c64\u7d30\u80de\u306b\u3001\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u5909\u5316\u304c\u8d77\u304d\u3066\u3001\u65b0\u305f\u306a\u89d2\u8cea\u5c64\u3092\u5f62\u6210\u3059\u308b\u9032\u5316\u304c\u8d77\u304d\u3066\u304d\u305f\u306e\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u9846\u7c92\u5c64\u7d30\u80de\u306e\u9069\u5fdc\u9032\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>&nbsp;\u3000\u79c1\u305f\u3061\u306f\u3001\u3053\u308c\u307e\u3067\u751f\u4f53\u5185\u306e\u9846\u7c92\u5c64\u7d30\u80de\u306e\u7d30\u80de\u6b7b\u904e\u7a0b\u3092\u3001\u751f\u304d\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3068\u5206\u96e2\u3057\u305f\u9846\u7c92\u5c64\u7d30\u80de\u3092\u7528\u3044\u3066\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3066\u304d\u307e\u3057\u305f\uff08\u52d5\u753b\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-video\"><video height=\"768\" style=\"aspect-ratio: 1024 \/ 768;\" width=\"1024\" controls src=\"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/wp-content\/uploads\/2022\/10\/SG1-movie.m4v\"><\/video><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u306e\u7d50\u679c\u3001\u9577\u671f\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u4e0a\u6607\u3068\u7d30\u80de\u5185\u9178\u6027\u5316\u304c\u9806\u756a\u306b\u8d77\u304d\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u6b7b\u7d30\u80de\u304c\u65b0\u305f\u306a\u6a5f\u80fd\u3092\u7372\u5f97\u3059\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u7d30\u80de\u6b7b\u6982\u5ff5\u300c\u30b3\u30eb\u30cd\u30aa\u30c8\u30fc\u30b7\u30b9\uff08Corneoptosis)\u300d\u3092\u63d0\u5531\u3057\u307e\u3057\u305f\u3002<br>\u300c<a href=\"https:\/\/www.riken.jp\/press\/2021\/20210420_2\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\" title=\"https:\/\/www.riken.jp\/press\/2021\/20210420_2\/index.html\">2021\u5e74 \u7406\u5316\u5b66\u7814\u7a76\u6240\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u76ae\u819a\u8868\u76ae\u7d30\u80de\u306e\u7d30\u80de\u6b7b\u904e\u7a0b\u3092\u89e3\u660e\uff0d\u7d30\u80de\u5185\u306e\u9178\u6027\u5316\u304c\u6b63\u5e38\u306a\u89d2\u5c64\u5f62\u6210\u306b\u91cd\u8981\uff0d<\/a>\u300d<br><a href=\"https:\/\/www.pnas.org\/content\/118\/17\/e2020722118\">Matsui et al., A unique mode of keratinocyte death requires intracellular acidification PNAS 118:e2020722118, 2021<\/a><br>(<a href=\"https:\/\/www.pnas.org\/content\/118\/22\/e2106633118\/tab-figures-data\">Commentary in PNAS by Jessica L. Moorea and Prof. Valentina Greco.<\/a>)<\/p>\n\n\n\n<p>&nbsp;\u3000\u4e00\u65b9\u3067\u3001\u65b0\u3057\u3044\u7a2e\u306e\u767a\u751f\u6642\u306b\u306f\u3001\u6838\u306e\u4e2d\u306e\u30b2\u30ce\u30e0DNA\u306e\u5909\u5316\u304c\u91cd\u8981\u306a\u8981\u7d20\u3068\u306a\u308a\u307e\u3059\u304c\u3001\u9678\u4e0a\u810a\u690e\u52d5\u7269\u30b2\u30ce\u30e0\u306e\u534a\u5206\u4ee5\u4e0a\u3092\u5360\u3081\u3066\u3044\u308b\u8ee2\u79fb\u56e0\u5b50\uff08\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\uff09\u304c\u3001\u89d2\u5c64\u306e\u5909\u5316\u306b\u4e0e\u3048\u305f\u5f71\u97ff\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<br><br>2011\u5e74\u306b\u3001\u79c1\u9054\u304c\u5831\u544a\u3057\u305f\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u7531\u6765\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u6a5f\u80fd\u89e3\u6790\u7d50\u679c\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u7531\u6765\u306e\u914d\u5217\u304c\u3001\u54fa\u4e73\u985e\u51fa\u73fe\u6642\u306e\u89d2\u5c64\u306e\u4fdd\u6e7f\u306b\u95a2\u308f\u3063\u305f\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<br>\u300c<a href=\"https:\/\/www.tmd.ac.jp\/mri\/press\/press13\/index.html\" title=\"https:\/\/www.tmd.ac.jp\/mri\/press\/press13\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">2011\u5e74 \u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u76ae\u819a\u9846\u7c92\u5c64\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u5185\u5728\u6027\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u578b\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u30d7\u30ed\u30c6\u30a2\u30fc\u30bcSASPase\u304c\u89d2\u8cea\u5c64\u6c34\u5206\u91cf\u306e\u8abf\u7bc0\u3092\u884c\u3046\u4e8b\u3092\u767a\u898b<\/a>\u300d<\/p>\n\n\n\n<p>\u65e5\u672c\u8a9e\u53c2\u8003\u7dcf\u8aac\uff1a\u300c<a href=\"http:\/\/jsv.umin.jp\/journal\/v66-1pdf\/virus66-1_031-038.pdf\" target=\"_blank\" rel=\"noreferrer noopener\" title=\"http:\/\/jsv.umin.jp\/journal\/v66-1pdf\/virus66-1_031-038.pdf\">\u9678\u4e0a\u810a\u690e\u52d5\u7269\u306e\u76ae\u819a\u306e\u9069\u5fdc\u9032\u5316\u3068\u5185\u5728\u6027\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u3000\u30a6\u30a4\u30eb\u30b9 \u7b2c&nbsp;66&nbsp;\u5dfb \u7b2c&nbsp;1&nbsp;\u53f7\uff0cpp.31-38\uff0c2016<\/a>\u300d<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306b\u9032\u5316\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u89b3\u70b9\u304b\u3089\u3001\u69d8\u3005\u306a\u89e3\u6790\u6280\u8853\u3092\u99c6\u4f7f\u3057\u3066\u3001\u9846\u7c92\u5c64\u7d30\u80de\u306e\u9069\u5fdc\u9032\u5316\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3001\u7f8e\u3057\u3044\u808c\u304c\u3069\u306e\u3088\u3046\u306b\u5f62\u6210\u3055\u308c\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>=========<br>2022\u5e745\u670816\u65e5\u3000\u6771\u4eac\u4fdd\u5065\u533b\u7642\u5c02\u9580\u8077\u5927\u5b66\u306e\u4f50\u3005\u6728\u535a\u4e4b\u535a\u58eb\u3089\u3068\u306e\u5171\u540c\u7814\u7a76\u6210\u679c\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u5f93\u6765\u306f\u9162\u9178\u30a6\u30e9\u30f3\u3068\u3044\u3046\u653e\u5c04\u6027\u7269\u8cea\u3092\u4f7f\u308f\u306d\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u304c\u5927\u304d\u306a\u554f\u984c\u3067\u3057\u305f\u3002\u75c5\u7406\u7d44\u7e54\u5207\u7247\u3092\u4e00\u822c\u7684\u306b\u67d3\u8272\u3059\u308b\u3053\u3068\u306b\u7528\u3044\u3089\u308c\u308b\u30de\u30a4\u30e4\u30fc\u30d8\u30de\u30c8\u30ad\u30b7\u30ea\u30f3\u3092\u96fb\u5b50\u9855\u5fae\u93e1\u8a66\u6599\u5207\u7247\u306e\u67d3\u8272\u306b\u7528\u3044\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u5831\u544a\u3067\u3059\u3002\u5f93\u6765\u3088\u308a\u3082\u5b89\u4fa1\u3067\u5b89\u5168\u306a\u67d3\u8272\u6cd5\u306e\u63d0\u6848\u3067\u3059\u3002<br><br><a href=\"https:\/\/www.nature.com\/articles\/s41598-022-11523-y%20\">Sasaki\u00a0H, Arai\u00a0H, Kikuchi\u00a0E, Saito\u00a0H, Seki K,\u00a0Matsui T:\u00a0Novel electron microscopic staining\u00a0method using traditional dye,\u00a0hematoxylin. Sci Rep. 12:7756, 2022.<\/a><br><br><a href=\"https:\/\/www.teu.ac.jp\/press\/2022.html?id=99\">\u65e5\u672c\u8a9e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1a\u65b0\u305f\u306a\u96fb\u2f26\u9855\u5fae\u93e1\u8a66\u6599\u306e\u67d3\u2f8a\u6cd5\u3092\u958b\u767a&#8211;\u5b89\u5168\u6027\u3001\u30b3\u30b9\u30c8\u3001\u6271\u3044\u6613\u3055\u306a\u3069\u306b\u512a\u308c\u305f\u2f3f\u6cd5\u3068\u3057\u3066\u671f\u5f85&#8211;<\/a><br><br><a href=\"https:\/\/www.teu.ac.jp\/english\/information\/2022\/0517.html\">English Press Release: Development of a new staining method for electron microscope specimens &#8211;Expected to be a safe, cost-effective, and easy-to-use method&#8211;<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research in Japanese \u3010\u7f8e\u3057\u3044\u808c\u306f\u3069\u306e\u3088\u3046\u306b\u3067\u304d\u308b\u306e\u304b\uff1f\u76ae\u819a\u306e\u9069\u5fdc\u9032\u5316\u304b\u3089\u8003\u3048\u308b\u89d2\u5c64\u30d0\u30ea\u30a2\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u3011 \u3000\u79c1\u9054\u306e\u7f8e\u3057\u3044\u808c\u306f\u3001\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u4f5c\u3089\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u76ae\u819a\u306f\u4eba\u4f53\u306e\u4e2d\u3067\u306e\u6700\u5927\u306e\u81d3\u5668 &#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":25,"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":737,"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/737"}],"wp:attachment":[{"href":"https:\/\/takeshi-matsui-lab.bs.teu.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}